Bagomet inhibits hepatic gluconeogenesis, reduce the absorption of glucose from the intestine, increases peripheral glucose utilization and improves the sensitivity of tissues to insulin. When this has no effect on insulin secretion of pancreatic beta cells. It reduces the level of triglycerides and low-density lipoprotein in blood. Stabilizes or reduces body weight. It has fibrinolytic action due to suppression of tissue plasminogen activator inhibitor type. After ingestion Bagomet absorbed from the gastrointestinal tract. The bioavailability after ingestion of standard doses of 50-60%. The maximum plasma concentration is reached 2 hours after ingestion. Almost does not bind to plasma proteins. It accumulates in the salivary glands, liver and kidneys. Provided unchanged by the kidneys. The half-life is about 6.5 hours. If the kidney function can be drug accumulation.
Diabetes mellitus type 2 without a tendency to ketoacidosis (especially in patients who are obese) when poor diet.
- diabetic ketoacidosis, diabetic precoma, coma;
- pronounced renal dysfunction;
- cardiac and respiratory failure, acute phase of myocardial infarction, acute testosterone suspension side effects cerebrovascular accident, dehydration, chronic alcoholism, and other conditions that may contribute to the development of lactic acidosis;
- Pregnancy and breast-feeding;
- Hypersensitivity to the drug.
- major surgery or injury, when shown of insulin;
- liver dysfunction, acute alcohol poisoning;
- lactic acidosis (including history);
- use for at least 2 days prior to and within 2 days after the radioisotope or radiological examinations introduction iodinated contrast material;
- compliance with a hypocaloric diet (less than 1000 calories / day).
Do not use the drug in patients older than 60 years, performing heavy physical work, which is associated with an increased risk of developing lactic acidosis.
Dosage and administration The dose is established by the doctor individually, depending on the level of glucose in the blood. The initial dose of 500-1000 mg / day. After 10-15 days may further gradual increase in the dose depending on the glucose level. The maintenance dose is usually 1500-2000 mg / day. The maximum dose – 3000 mg / day. To reduce the side effects from the gastrointestinal tract daily dose should be divided in 2 3 receptions. In elderly patients the recommended daily dose should not exceed 1000 mg. Bagometa tablets should be taken as a whole during or immediately after a meal with a small amount of liquid ( a glass of water). Due to the increased risk of lactic acidosis, Bagometa dose should be reduced in severe metabolic disorders.
Side effect On the part of the digestive organ system: nausea, vomiting, “metallic” taste in the mouth, loss of appetite, diarrhea, flatulence, abdominal pain. On the part of metabolism: rarely – lactic acidosis (requires discontinuation of treatment); long-term treatment – vitamin deficiencies in 12 (malabsorption). From the side of hematopoiesis : in some cases – megaloblastic anemia. From the Endocrine : hypoglycemia (when used in inadequate doses). Allergic testosterone suspension side effects reactions : skin rash.
In case of overdose may develop lactic acidosis Bagometa fatal. The reason for the development of lactic acidosis may also be the accumulation of the drug due to renal dysfunction. Early symptoms of lactic acidosis include nausea, vomiting, diarrhea, drop in body temperature, abdominal pain, pain in the muscles, in the future may be marked shortness of breath, dizziness, impaired consciousness and coma develop. Treatment : In case of occurrence of lactic acidosis symptoms, treatment Bagometom you must immediately stop testosterone suspension, the patient hospitalized immediately and determine the concentration of lactate, to confirm the diagnosis. The most effective measure for removal from the body and Bagometa lactate is hemodialysis. Spend as symptomatic treatment. In combination therapy with sulfonylurea Bagometa may develop hypoglycaemia.
Interaction with other medicinal products In an application with sulfonylureas, acarbose, insulin, nonsteroidal anti-inflammatory agents, monoamine oxidase inhibitors, oxytetracycline, angiotensin converting enzyme inhibitors, clofibrate derivatives, cyclophosphamide, ß-blockers may increase the hypoglycemic effect Bagometa. While the use of corticosteroids, oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormone drugs, thiazide and “loop” diuretics, phenothiazine derivatives, derivatives of nicotinic acid may reduce the hypoglycemic action Bagometa. Cimetidine Bagometa slows down, resulting in increased risk of developing lactic acidosis. Bagomet may weaken the effect of anticoagulants (coumarin derivatives). Together with the admission of alcohol may develop lactic acidosis.
Cautions During treatment necessary to monitor renal function. At least 2 times a year, as well as the appearance of myalgia should determine the content of lactate in plasma. Bagometa possible to use in testosterone suspension side effects combination with sulfonylureas. In this case, you need particularly careful monitoring of blood glucose levels. buy legal anabolic steroids online
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