The presence in the structure acetylcysteine sulfhydryl groups helps break the disulfide bonds, acid mucopolysaccharides mucus, which leads to a reduction of mucus viscosity. The drug remains active in the presence of purulent sputum. When prophylactic use of acetylcysteine marked decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.
Respiratory diseases accompanied by formation viscous sputum; acute and chronic bronchitis, obstructive bronchitis, laryngotracheitis, pneumonia, bronchiectasis, asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis, cystic fibrosis. Acute and chronic sinusitis, inflammation of the middle ear (otitis media).
Increased sensitivity to acetylcysteine or other components of the drug, pregnancy, lactation. Be wary – gastric ulcer and duodenal ulcer in the acute stage;hemoptysis, pulmonary hemorrhage, esophageal varices, asthma, diseases of the adrenal glands, liver and / or kidney failure, children up to 2 years (use is possible only if there is evidence of life and strict medical supervision).
Pregnancy and lactation
The safety measures due to insufficient amount of data, use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.
Dosing and Administration
In the absence of other nominations recommended to adhere to the following dosage: Adults and adolescents over the age of 14 years: It is recommended to take 2-3 times a day for 2 scoops (= 10 ml) of the drug, which corresponds to receiving 400-600 mg of acetylcysteine day.
Children aged 6-14 years:
It is recommended to take 3-4 times a day for 1 measuring spoon (= 5 ml) of the drug, which corresponds to receiving 300-400 mg of acetylcysteine per day.
Children aged 2-5 years:
It is recommended to take 2-3 times a day for 1 measuring spoon (= 5 ml) of the drug. corresponding reception 200-300 mg per day acetylcysteine.
Children less than 2 years (only on doctor’s orders):
It is recommended to take 2-3 times a day for Vz measuring spoon (= 2.5 ml) of the drug, which corresponds to receiving 100-150 mg of acetylcysteine per day,
There is a sufficient amount of the dosage of the drug in the newborn data.
patients with cystic fibrosis (an inborn error of metabolism with frequent infections of the bronchial passages) and weighing more than 30 kg is possible to increase the daily dose to 800 mg.
Children over the age of b years: Recommended 3 times daily intake of 2 scoops (= 10 ml) of the drug, corresponding to receive 600 mg of acetylcysteine per day.
Children 2-6 years:
Recommended 4 times daily administration and 1 scoop of the preparation (= 5 mL), which corresponds to receiving 400 mg per day acetylcysteine.
Infants, starting from the 10th day of life, or small children aged less than 2 years:
Recommended 3 times daily intake by 1/2 measuring spoon of the drug (= 2.5 ml), which corresponds to receiving 150 mg of acetylcysteine per day .
Treatment should be started gradually under medical supervision.
Additional fluid intake increases the mucolytic effect of the drug.
In the short-term duration of colds reception is 5-7 days. At long disease duration of therapy is determined by the attending physician. In chronic bronchitis and cystic fibrosis drug should be taken over a long period of time to achieve a preventive effect against infections.
Note for diabetics:
10 ml (= 2 scoops) of ready-to-drink testosterone suspension reviews contain 3,7g D-glucitol (sorbitol), which corresponds to the 0S31 BE.
In rare cases, there are headaches, inflammation of the oral mucosa (stomatitis), and tinnitus. Very rarely – diarrhea, vomiting, heartburn and nausea, decreased blood pressure, increased heart rate (tachycardia). In rare cases, allergic reactions such as bronchospasm (predominantly in patients with bronchial hyperreactivity), skin rash, itching and hives. In addition, there are few reports of bleeding due to the presence of hypersensitivity reactions.
In developing side effects should stop taking the drug and consult a doctor.
If erroneous or deliberate overdose observed phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea. Until now there was no serious and life-threatening side effects.
Interaction with other drugs
With simultaneous use of acetylcysteine and antitussives because of the suppression of the cough reflex may be stagnant mucus. Therefore, such combinations should be selected with caution.Simultaneous administration of acetylcysteine and nitroglycerin may lead to increased vasodilatory action subsequent. Pharmaceutical incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.
In contact with metals, rubber formed sulfides with a characteristic odor.
Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after oral administration of acetylcysteine).
Patients with bronchial asthma and obstructive bronchitis acetylcysteine should be used with caution under systematic control of bronchial obstruction.
In the treatment of patients with diabetes need to take into account that the drug contains sorbiton.
When working with the preparation necessary to use glassware, avoid contact with metal, rubber, oxygen, oxidizing agents easily.
Granules for testosterone suspension reviews (orange).
30 g of granulate for the preparation of 75 ml of testosterone suspension reviews in a bottle of dark glass or
60 g of granulate for the preparation of 150 ml of testosterone suspension reviews in a bottle of dark glass.
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