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Combined drug, neurotropic B vitamins (thiamine, pyridoxine, cyanocobalamin) have a beneficial effect on inflammatory and degenerative diseases of the nerves and the skeletal system. They do not apply to eliminate gipovitaminoznyh states, and in high doses have analgeticheskimim properties, promote blood flow and normalize the nervous system, the process of hematopoiesis (cyanocobalamin (vitamin B12)). Vitamins Thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) regulate protein, carbohydrate and fat metabolism, promote normalization improve motor function, sensory and autonomic nerves. testosterone suspension results – local anesthetic.

Pharmacokinetics
After intramuscular thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing, 50 mg) and unevenly distributed in the body when its content in leukocytes of 15% red blood cells of 75% and plasma 10 %. Thiamine penetrates the blood-brain and placental barriers, is found in breast milk. Thiamine kidneys displayed in the alpha-phase by 0.15 hours, the beta phase – after 1 hour in the terminal phase – for 2 days. The major metabolites are tiaminkarbonovaya acid Pyramin and some unidentified metabolites. Of all the vitamins thiamine stored in the body in small amounts. An adult human contains about 30 mg of thiamine as 80% in the form of thiamine pyrophosphate, thiamine triphosphate 10% and the remainder in the form of thiamine monophosphate. After intramuscular injection of pyridoxine is rapidly absorbed from the injection site and distributed in the body, acting as a coenzyme after phosphorylation CH2OH group in the 5th position. About 80% of vitamin binds to plasma proteins. Pyridoxine is distributed throughout the body, crosses the placenta, it is found in breast milk. Stored in the liver and is oxidized to 4-pyridoxine acid which is excreted by the kidneys, a maximum 2-5 hours after absorption.

Indications for use:

In the treatment of diseases of the nervous system of various origins:

  • neuritis and polyneuritis, including optic neuritis;
  • neuralgia, including trigeminal nerve and intercostal nerves;
  • peripheral paresis, including facial nerve;
  • pain (radicular, myalgia);
  • plexopathy, ganglionitis (including herpes zoster);
  • neuropathy and polyneuropathy (diabetic, alcohol, etc..);
  • nocturnal muscle cramps, especially in patients of older age groups;
  • neurological manifestations of osteochondrosis (radiculopathy, sciatica, muscular-tonic syndrome).

 

Contraindications:

 

  • Hypersensitivity to the drug;
  • acute heart failure, chronic heart failure in the stage of decompensation;
  • thrombosis and thromboembolism;
  • Children up to age 18 years (effectiveness and safety have not been established).

 

Pregnancy and lactation

During pregnancy and lactation is not recommended to use the drug.

Dosing and Administration

The drug is recommended to be administered intramuscularly deeply. Duration of treatment is determined by the physician individually depending on the severity of symptoms.

When expressed pain syndrome 2 ml (1 ampoule) daily for 5-10 days, followed by 2 ml (1 ampoule) 2-3 times a week in the credit score to 2 weeks. For maintenance therapy is recommended that use of oral forms of vitamin B.

Side effect

Allergic reactions (skin reactions such as pruritus, urticaria), sweating, tachycardia, may cause acne, dyspnea, angioedema, anaphylactic shock.

In cases of very rapid administration may be systemic adverse reactions (dizziness, headache, arrhythmia, seizures), they can also be the result of an overdose.

If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

Overdose

Symptoms: increased side effects of the drug symptoms. Treatment: symptomatic therapy.

Interaction with other drugs

Thiamine completely dissolves in solutions containing sulphites. Other vitamins thiamine inactivated in the presence of degradation products. Thiamine is incompatible with oxidizing and reducing substances: mercuric chloride, iodide, carbonate, acetate, tannic acid, ammonium-iron-citrate and phenobarbital, riboflavin, benzylpenicillin, dextrose and metabisulfite. Copper ions, the values of pH (greater than 3.0) accelerate the destruction of thiamine.

Pyridoxine is not administered with levodopa, tsiklossrinom, D-penicillamine, epinephrine, porepinefrinom, sulfonamides, which reduce the effect of pyridoxine.

Cyanocobalamin is incompatible with ascorbic acid, salts of heavy metals. Taking into account the presence in the formulation of testosterone suspension results in case of the additional use of epinephrine and norepinephrine possible increased side effects on the heart. In case of overdose of local anesthetics can not be further used epinephrine and norepinephrine.

Product form:

The solution for intramuscular injection.

2 ml of the drug in the ampule lightproof neutral glass.

5 vials are placed in a contoured plastic packaging (pallet) from polyvinyl chloride film, or polyethylene terephthalate film.

5 vials are placed in blisters made of PVC film or polyethylene terephthalate film, aluminum foil and printed patent or packaging material.

1, 2, 4-outline plastic packages (pallets) or blisters with ampoules, together with instructions for use and a knife or lancet ampoule ampoule is placed in a pile of cardboard.

5, 10, 20 ampoules but with instruction use and knife or lancet ampoule ampoule is placed in a wad of cardboard divider insert. When using ampoules with a color break point and a notch or color break-ring, knife scarifier ampoule or ampoule do not invest. anabolic steroids online shop

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