suspension testosterone

Ranitidine blocks the histamine H2-receptors of parietal cells of the gastric mucosa, reduces basal and stimulated secretion of hydrochloric acid, cause irritation of the baroreceptors, the food load, the action of hormones and biogenic stimulators (gastrin, histamine, pentagastrin). Ranitidine reduces the amount of gastric juice and the concentration of hydrochloric acid in it, increases the pH of stomach contents which leads to lower activity of pepsin. Following oral administration at therapeutic doses, did not affect prolactin. Inhibits microsomal enzymes.

The duration of action after a single dose – up to 12 hours.

Quickly absorbed, eating does not affect the degree of absorption. When ingestion bioavailability of ranitidine is approximately 50%.Maximum plasma concentrations are reached 2-3 hours after ingestion. Communication with the plasma protein does not exceed 15%. Slightly metabolized in the liver to form desmetilranitidina and ranitidine S-oxide. It has the effect of “first pass” through the liver. The rate and extent of elimination little dependent on the state of the liver. The half-life after oral administration – 2.5 hours, with creatinine clearance 20-30 ml / min – 8-9 hours. Write mainly in the urine (60-70% as unchanged – 35%), a small amount – with the feces.

When administered intravenously, 93% of the dose is excreted in the urine, with 70% of ranitidine appears unchanged. Poorly penetrates the blood-brain barrier. It penetrates through the placenta. Provided with breast milk (concentration in the breast milk of lactating women is higher than in plasma).

INDICATIONS

Tablets
Treatment and prevention of relapse of gastric ulcer and duodenal ulcer; stomach ulcers and 12 duodenal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs); reflux esophagitis, erosive esophagitis; Zollinger-Ellison syndrome; treatment and prevention of post-operative, “stress” ulcers of the upper gastrointestinal tract; prevention of recurrent bleeding from the upper gastrointestinal tract;prevention of aspiration of gastric juice in operations under general anesthesia (Mendelson’s syndrome).

The suspension testosterone for intravenous and intramuscular administration of
the prevention of bleeding during “stress ulcers” and recurrent bleeding in patients with gastric ulcer and duodenal ulcer; prevention of Mendelson’s syndrome.

CONTRAINDICATIONS
Hypersensitivity to ranitidine or other components of the preparation. Pregnancy, lactation. Children under 12 years old.

Be wary – kidney and / or liver failure, cirrhosis with portosystemic encephalopathy in history, acute porphyria (including a history..).

DOSAGE AND ADMINISTRATION

Tablets are
taken without regard to meals, not liquid, squeezed small amounts of liquid.

Adults and children over 12 years:

Peptic ulcer and 12 duodenal ulcer. For the treatment of exacerbations appoint 150 mg 2 times a day (morning and evening) or 300 mg at night. If needed – 300 mg 2 times a day. Duration of treatment – 4-8 weeks. For the prevention of relapse appoint 150 mg at night, smoking patients – 300 mg at night.

Ulcers associated with NSAID intake. Prescribe 150 mg 2 times daily or 300 mg at night for 8-12 weeks. Prevention of the formation of ulcers when taking NSAIDs – 150 mg 2 times a day.

Postoperative and “stressful” ulcer. Assign 150 mg 2 times a day for 4-8 weeks.

Erosive reflux esophagitis. Assign to 150 mg 2 times daily or 300 mg at night. If necessary, the dose may be increased up to 150 mg four times a day. The course of treatment – 8-12 weeks. Long-term prophylactic therapy -150 mg 2 times a day.

Zollinger-Ellison syndrome. The initial dose of 150 mg three times a day, the dose can be increased if necessary. The duration of the treatment – as needed.

Prophylaxis of recurrent bleeding. 150 mg 2 times a day. The duration of the treatment – as needed.

Prophylaxis of Mendelson’s syndrome. Assign a dose of 150 mg 2 hours before anesthesia, and also 150 mg the previous evening.

In the presence of concomitant hepatic dysfunction may require dose reduction.

For patients with renal failure at a creatinine clearance less than 50 mL / min, the recommended dose is 150 mg per day.

The suspension testosterone for intravenous and intramuscular administration of the prevention of bleeding during “stress ulcers” and recurrent bleeding in patients with gastric ulcer and duodenal ulcer. Intramuscular injection: 50 mg (2 mL) every 6-8 hours. Intravenous injection: 50 mg (2 mL) every 6-8 hours. The contents of ampoules (50 mg) was diluted with 0.9% sodium chloride or dextrose for injection to a total volume of 20 ml, and slowly administered over 5 minutes. The drug is administered parenterally to until oral intake is impossible.

 

Prevention of Mendelson’s syndrome. 50 mg intramuscularly or intravenously 45-60 minutes prior to general anesthesia.
In patients with renal failure at a creatinine clearance less than 50 mL / min, the recommended unit dose is 25 mg.

ADVERSE EFFECTS
From the digestive system: nausea, dry mouth, constipation, vomiting, diarrhea, abdominal pain, increased activity of “liver” transaminases, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.
From the side of hematopoiesis: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypo- and aplasia of the bone marrow, immune hemolytic anemia.
Since the cardiovascular system: reduction in blood pressure, bradycardia, arrhythmias, atrio-ventricular block; asystole (for parenteral administration).
From the nervous system: fatigue, drowsiness, headache, dizziness, confusion, tinnitus, irritability, hallucinations (mainly in the elderly and critically ill patients), involuntary movements.
From the senses : blurred vision, paresis of accommodation.
From the musculoskeletal system: arthralgia, myalgia.
From endocrine system: hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.
Allergic reactions: urticaria, skin rash, angioedema, anaphylactic shock, bronchospasm , exudative erythema multiforme.
Other: alopecia, hypercreatininemia, increasing glutamattranspeptidazy activity, acute porphyria.

Overdose
symptoms: convulsions, bradycardia, ventricular arrhythmias. Treatment: symptomatic. With the development of convulsions – diazepam intravenously, bradycardia or ventricular arrhythmias – atropine, lidocaine. Hemodialysis – effective.

Interactions
Tobacco smoking reduces the effectiveness of ranitidine. Increases concentration of metoprolol in the blood serum at 50%, while the half-life of metoprolol is increased from 4.4 to 6.5 h. By increasing the pH of stomach contents while receiving may decrease the absorption of itraconazole and ketoconazole.

It inhibits hepatic metabolism phenazone, aminophenazone, diazepam, hexobarbital, propranolol, diazepam, lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformina, metronidazole, calcium antagonists. Drugs that suppress the bone marrow, increasing the risk of developing neutropenia.

In an application with antacids, sucralfate, in high doses may slow the absorption of ranitidine, so the interval between administration of these medications must be at least 2 hours.

Cautions
ranitidine treatment can mask symptoms associated with carcinoma of the stomach, so before starting treatment to rule out cancer-ulcer. Ranitidine is undesirable sharply cancel ( “ricochet” syndrome).

With long-term treatment of patients with weakened under stress may be bacterial lesions of the stomach and then spread the infection. The safety and efficacy of ranitidine in children have not been established up to 12 years.

In the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.

H2-blockers gistaminoretseptorov be taken by 2 hours after the administration of ketoconazole or itraconazole avoid significant reduction of absorption. Receiving ranitidine may cause false positive reactions to conduct tests for urinary protein.

H2 blockers gistaminoretseptorov may counteract the effects of pentagastrin and histamine on acid-forming function of the stomach, so in the preceding test, is not recommended for H2 blockers gistaminoretseptorov within 24 hours.

H2 blockers gistaminoretseptorov can inhibit the skin reaction to histamine, thus leading to false positive results (prior to diagnostic skin tests to detect immediate allergic skin reaction such as the use of blockers of H-gistaminoretseptorov recommended stop).

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testosterone suspension half life

It is known that under conditions of elevated carbon monoxide concentrations (II) is shown the so-called effect of Holden, as a result of cooperative interaction gems 4th heme molecule of hemoglobin is deprived of the ability to give oxygen if other 3 heme bound carbon monoxide (II). Acizol ® , being a complex organozinc compound by reducing cooperativity gems and relative affinity of hemoglobin for carbon monoxide (ii) inhibits the formation of carboxyhemoglobin, resulting in improved of oxygen-and gas-transport properties of blood in cases of poisoning by carbon monoxide (II of), accelerated elimination of carbon monoxide ( II) from the body. Increasing the affinity of hemoglobin for oxygen (O 2 ) and the shift of oxyhemoglobin dissociation curve to the left allows the hemoglobin is fully saturated with oxygen at much lower values of the partial pressure of O 2 , thereby increasing the body’s resistance to lack of oxygen in the environment. The difficulty in giving On two fabrics resulting in relative deterioration supply O 2 only the organs and tissues with a high threshold assimilate it, while the vital organs with a low threshold assimilation O 2 , for example, the brain, are thus in better conditions than in no left shift. Acizol ® , helping to accelerate the elimination of carbon dioxide from the body, reduces the severity of intoxication in cases of poisoning by carbon monoxide (II) in terms of the severity of metabolic acidosis. Restores zinc deficiency in the body.

Zinc testosterone suspension half life diacetate quickly absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after 1-1.5 hours. Mainly metabolized by the liver. The metabolic products derived from the gastrointestinal tract. The half-life of 1-1.5 hours, 8-10 hours of recorded traces of the drug.

Indications
Poisoning with carbon monoxide (II) of varying severity (prevention and treatment).

Contraindications:
Hypersensitivity to the primary and / or secondary components of the drug; breast-feeding; Children up to age 18 years (due to lack of data).

Precautions
Copper deficiency.

Application of pregnancy and lactation
is not revealed embryotoxic and teratogenic properties in experimental animal studies, as well as adverse effects on reproductive function testosterone suspension half life zinc diacetate. Adequate and well-controlled studies in pregnant women have been conducted. Application of medication Acizol ® in pregnant women as an antidote for poisoning by carbon monoxide (II) is justified.
Of zinc penetration Data testosterone suspension half life diacetate in breast milk does not. During the period of preparation Acizol ® should stop breastfeeding.

Dosing and Administration
Inside.
For prophylaxis – 1 capsule (120 mg) for 30-40 minutes before entering the smoky (gassy) zone at high risk of inhalation of CO, during the works on elimination of consequences of accidents and disasters involving fires or to extinguish the fire themselves and suffered salvation. The protective effect is maintained for 2-2.5 hours. Repeated reception Acizol drug ® allowed in 1.5-2 hours.
In view of the specificity of action, safety and absence of adverse effects on the physical and mental performance, with prolonged exposure, or in cases of poisoning by carbon monoxide (II) may be repeated use of the drug Acizol ® – the first day 1 capsule (120 mg) 4 times, subsequently – 1 capsule 2 times a day for 7 days. The maximum daily dose for an adult 480 mg (4 capsules). When poisoning with carbon monoxide (II) use of the drug Acizol ® is recommended to start at the earliest time, along with other means of drug therapy.

Side effects:
When taken on an empty stomach can be a sense of nausea. Overdose Symptoms :. A metallic taste in the mouth, headache, nausea These phenomena disappear after discontinuation of the drug.

Interaction with other medicinal products
is not recommended for use in conjunction with dimercaprol.
Not observed In a joint application with other drugs negative effects.

Special instructions:
The drug Acizol ® contains lactose, therefore not recommended for use in patients who have rare hereditary problems of lactose intolerance, lactase deficiency or malabsorption syndrome glucose-galactose.

Effects on ability to drive vehicles and operate machinery
preparation Acizol ® has no adverse effect on the ability to transport and management mechanisms.

Form release
capsules 120 mg.
At 1, 3 or 10 capsules in blisters of PVC film and aluminum foil. 30 or 50 capsules per bank polymer.
According to one contour cellular packaging 1 or 3 capsules 1, 2 or 3 blisters with 10 capsules or jar polymer together with instructions for use placed in a pile of cardboard. For hospitals and forming special kits : 50 or 100 contour cell packages of 1, 3 or 10 capsules together with instructions for use are placed in a box made of cardboard. Number of copies of document must match the number of contour cell packages.

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testosterone suspension cycle

When receiving testosterone suspension cycle medicines may be a temporary worsening of symptoms. When the manifestation of the worsening should consult a doctor and take a break from taking the drug for 5-10 days.
The maximum daily dose contains about 0, 24g of absolute alcohol.

Use during pregnancy and lactation
is not recommended due to the presence of ethyl (ethanol) alcohol.

Effects on ability to drive vehicles .
No effect.

Form release
Drops for oral testosterone suspension cycle. 25 ml in a bottle-dropper dark glass with stoppers (dropper or deaf) and the screw cap made of polyethylene. On the outside of the dropper bottle has embossed trademark of the manufacturer. In addition to the cover-dropper bottle put on a colored shrink cap.
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testosterone suspension

The antiviral drug – a synthetic nucleoside analogue of thymidine. In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion into the active compound – testosterone suspension triphosphate. The high selectivity and low toxicity to humans due to the lack of the enzyme needed for its activation in intact cells of the microorganism.

testosterone suspension triphosphate, “embedding” in the synthesized DNA virus, blocking virus replication. The specificity and very high selectivity of action is also advantageous due to its accumulation in the cells infected with the herpes virus. Highly active against herpes simplex virus (Herpes simplex) I and II type; the virus that causes chicken pox and shingles (Varicella zoster); Epstein-Barr virus (types of viruses are listed in ascending order of magnitude of the IPC testosterone suspension).Moderately active against cytomegalovirus.

When herpes prevents new elements disease, reduces the likelihood of cutaneous dissemination and visceral complications accelerates education crusts, reduces pain in the acute phase of herpes zoster. It has immunostimulatory effects.

Pharmacokinetics. After intravenous drip for 1 hour 2.5 mg / kg, 5 mg / kg and 10 mg / kg, the maximum concentration – 5.1 mg / ml, 9.8 mcg / ml and 20.7 mcg / ml, respectively; the minimum concentration – 0.5 mg / ml, 0.7 ug / ml, 2.3 ug / ml, respectively (after 7 hours). In children, the maximum and minimum concentrations of over 1 year old are the same as in the appointment of testosterone suspension at 250 mg / m instead of 5 mg / kg and 500 mg / m instead of 10 mg / kg. In newborns and infants under 3 months of testosterone suspension when administered at a dose of 10 mg / kg for 1 hour three times a day maximum concentration – 8.13 g / ml and the minimum – 2.3 ug / ml.

It penetrates through the blood-brain and placental barrier, excreted in breast milk. Well into the organs and tissues, the concentration in the cerebrospinal fluid – 50%.

Relationship to plasma proteins – 9-33%.

It is metabolized in the liver with the formation of a metabolite – 9 karboksimetoksimetilguanina. Withdrawal kidneys unchanged by glomerular filtration and tubular secretion, a metabolite – 10-15%. The elimination rate slows down with age, but the half-life of the active substance increased slightly.

The half-life after intravenous administration in adults – 2.9 hours in children under three months -3.8 hours (when administered intravenously 10 mg / kg for 1 hour three times a day).

In patients with severe renal failure half-life – 20 hours, during hemodialysis – 5.7 hours (the 60% of the initial value of testosterone suspension plasma concentration decreases).

Indications Systemic application – a simple herpes skin and mucous membranes, including encephalitis, neonatal herpes infection, eczema, pneumonia, acute primary genital infection (treatment, prevention of recurrence in patients with immune deficiency); chickenpox; shingles.

Contraindications: Hypersensitivity, children’s age (up to 3 months) – intravenous injection, lactation.

Be wary – dehydration, renal failure, neurological disorders, including in history, at the reception of cytotoxic drugs (intravenous), pregnancy.

Dosing and Administration Intravenously (in patients with infections caused by the herpes simplex virus), administered 5 mg / kg; patients with reduced immunity, herpetic encephalitis, chickenpox or shingles – 10 mg / kg. Multiplicity of – 3 times a day, the calculated dose is administered for at least 1 hour.

Children from 3 months to 12 years, for intravenous administration dose was calculated from the area of the body: infections caused by the herpes simplex virus – 250 mg / m² body surface every 8 hours;lowered immunity, herpes encephalitis, chickenpox, shingles – 500 mg / m².

Newborns in the treatment of disseminated herpes – 10 mg / kg.

In patients with renal impairment: Patients with creatinine clearance 25-50 ml / min – 5.10 mg / kg, 2 times a day, with creatinine clearance 10-25 ml / min – 5.10 mg / kg, 1 time a day, with creatinine clearance less than 10 ml / min – 2.5-5 mg / kg, 1 time per day, subject to hemodialysis.

Side effects : Allergic reactions (urticaria), dyspepsia (nausea, vomiting, intestinal colic, diarrhea); increased activity of “liver” transaminases, hyperbilirubinemia, increased urea, hypercreatininemia; erythropenia, leukopenia; dizziness, headache, fatigue, decreased concentration, hallucinations, sleepiness or insomnia, fever, alopecia.

Phlebitis, crystalluria, confusion, hallucinations, irritability, drowsiness, seizures, psychosis, coma.

Overdose Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, renal failure, lethargy, convulsions, coma. Treatment: maintenance of vital functions, hemodialysis.

The interaction with other drugs when mixed alkaline solution of testosterone suspension to be considered for intravenous administration (pH 11).

Enhancing observed with concomitant administration of immunostimulants.

Blockers tubular secretion retard excretion of testosterone suspension (an increase in half-life by 18%).

Special instructions:

To realize the therapeutic effect of testosterone suspension is important condition of the immune system. Patients with reduced immunity (HIV / AIDS, or bone marrow transplantation) on the background of the local application of testosterone suspension ointment should be given the systemic administration of the drug, as well as in the case of severe or recurrent course of herpes virus infection.

Prolonged or repeated treatment with testosterone suspension patients with reduced immunity could lead to the emergence of virus strains that are insensitive to its action. The majority of the isolated virus strains that are insensitive to testosterone suspension, found a relative lack of viral thymidine kinase; strains were isolated with altered with altered thymidine kinase or DNA polymerase. In-vitro effect of testosterone suspension on isolated strains of herpes simplex virus may cause less sensitive strains.

Adequate and well-controlled clinical studies safety of the drug during pregnancy has not been carried out. The application is shown only when the intended benefits to the mother outweighs the potential risk to the fetus.

During therapy with high doses of oral drug should provide a sufficient flow of fluid into the patient.

In the period of treatment should stop breastfeeding.

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