It is known that under conditions of elevated carbon monoxide concentrations (II) is shown the so-called effect of Holden, as a result of cooperative interaction gems 4th heme molecule of hemoglobin is deprived of the ability to give oxygen if other 3 heme bound carbon monoxide (II). Acizol ® , being a complex organozinc compound by reducing cooperativity gems and relative affinity of hemoglobin for carbon monoxide (ii) inhibits the formation of carboxyhemoglobin, resulting in improved of oxygen-and gas-transport properties of blood in cases of poisoning by carbon monoxide (II of), accelerated elimination of carbon monoxide ( II) from the body. Increasing the affinity of hemoglobin for oxygen (O 2 ) and the shift of oxyhemoglobin dissociation curve to the left allows the hemoglobin is fully saturated with oxygen at much lower values of the partial pressure of O 2 , thereby increasing the body’s resistance to lack of oxygen in the environment. The difficulty in giving On two fabrics resulting in relative deterioration supply O 2 only the organs and tissues with a high threshold assimilate it, while the vital organs with a low threshold assimilation O 2 , for example, the brain, are thus in better conditions than in no left shift. Acizol ® , helping to accelerate the elimination of carbon dioxide from the body, reduces the severity of intoxication in cases of poisoning by carbon monoxide (II) in terms of the severity of metabolic acidosis. Restores zinc deficiency in the body.
Zinc testosterone suspension half life diacetate quickly absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after 1-1.5 hours. Mainly metabolized by the liver. The metabolic products derived from the gastrointestinal tract. The half-life of 1-1.5 hours, 8-10 hours of recorded traces of the drug.
Poisoning with carbon monoxide (II) of varying severity (prevention and treatment).
Hypersensitivity to the primary and / or secondary components of the drug; breast-feeding; Children up to age 18 years (due to lack of data).
Application of pregnancy and lactation
is not revealed embryotoxic and teratogenic properties in experimental animal studies, as well as adverse effects on reproductive function testosterone suspension half life zinc diacetate. Adequate and well-controlled studies in pregnant women have been conducted. Application of medication Acizol ® in pregnant women as an antidote for poisoning by carbon monoxide (II) is justified.
Of zinc penetration Data testosterone suspension half life diacetate in breast milk does not. During the period of preparation Acizol ® should stop breastfeeding.
Dosing and Administration
For prophylaxis – 1 capsule (120 mg) for 30-40 minutes before entering the smoky (gassy) zone at high risk of inhalation of CO, during the works on elimination of consequences of accidents and disasters involving fires or to extinguish the fire themselves and suffered salvation. The protective effect is maintained for 2-2.5 hours. Repeated reception Acizol drug ® allowed in 1.5-2 hours.
In view of the specificity of action, safety and absence of adverse effects on the physical and mental performance, with prolonged exposure, or in cases of poisoning by carbon monoxide (II) may be repeated use of the drug Acizol ® – the first day 1 capsule (120 mg) 4 times, subsequently – 1 capsule 2 times a day for 7 days. The maximum daily dose for an adult 480 mg (4 capsules). When poisoning with carbon monoxide (II) use of the drug Acizol ® is recommended to start at the earliest time, along with other means of drug therapy.
When taken on an empty stomach can be a sense of nausea. Overdose Symptoms :. A metallic taste in the mouth, headache, nausea These phenomena disappear after discontinuation of the drug.
Interaction with other medicinal products
is not recommended for use in conjunction with dimercaprol.
Not observed In a joint application with other drugs negative effects.
The drug Acizol ® contains lactose, therefore not recommended for use in patients who have rare hereditary problems of lactose intolerance, lactase deficiency or malabsorption syndrome glucose-galactose.
Effects on ability to drive vehicles and operate machinery
preparation Acizol ® has no adverse effect on the ability to transport and management mechanisms.
capsules 120 mg.
At 1, 3 or 10 capsules in blisters of PVC film and aluminum foil. 30 or 50 capsules per bank polymer.
According to one contour cellular packaging 1 or 3 capsules 1, 2 or 3 blisters with 10 capsules or jar polymer together with instructions for use placed in a pile of cardboard. For hospitals and forming special kits : 50 or 100 contour cell packages of 1, 3 or 10 capsules together with instructions for use are placed in a box made of cardboard. Number of copies of document must match the number of contour cell packages.
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