When administered levothyroxine testosterone suspension gains is absorbed almost exclusively in the upper small intestine. Absorbed 80% of the dose of the drug. Food intake reduces the absorption of levothyroxine testosterone suspension gains.Maximum serum concentration is reached approximately 5-6 hours after ingestion. After absorption of more than 99% of the drug is bound to serum proteins (thyroxine-binding globulin, thyroxine binding prealbumin, and albumin). In various tissues occurs monodeyodirovanie about 80% levothyroxine testosterone suspension gains to form a triiodothyronine (T 3 ) and inactive ingredients. Thyroid hormones are metabolized mainly in the liver, kidney, brain and muscles. A small amount of the drug undergoes deamination and decarboxylation as well as sulfuric acid and conjugated with glucuronic acid (in the liver). The metabolites are excreted in the urine and bile. The half-life of 6-7 days. When thyrotoxicosis half-life is shortened to 3-4 days, and hypothyroidism is extended to 9-10 days.
- euthyroid goitre;
- as replacement therapy and for the prevention of goiter recurrence after resection of the thyroid gland;
- thyroid cancer (after surgery);
- diffuse toxic goiter: after achieving euthyroid state tireostatikami (in the form of combination or monotherapy);
- as a diagnostic tool for the test thyroid suppression.
- Individual hypersensitivity to the drug;
- Untreated hyperthyroidism;
- acute myocardial infarction, acute myocarditis;
- untreated adrenal insufficiency.
Precautions should be prescribed the drug for diseases of the cardiovascular system: ischemic heart disease (atherosclerosis, angina pectoris, myocardial infarction), hypertension, arrhythmia; diabetes, severe long-existing hypothyroidism, malabsorption syndrome (may require dose adjustment).
Use during pregnancy and lactation
During pregnancy and breast-feeding therapy with levothyroxine testosterone suspension gains, designated about hypothyroidism, should be continued. During pregnancy, you want to increase the dose of the drug due to increased levels of thyroxine-binding globulin. The amount of thyroid hormone secreted by breast milk during lactation (anavar for sale), is not sufficient to cause any impairment in children. Pregnancy drug in combination with tireostatikami contraindicated since receiving levothyroxine testosterone suspension gains may require an increase in dose thyreostatics. Since tireostatiki unlike levothyroxine testosterone suspension gains, can cross the placenta, the fetus may develop hypothyroidism. During the period of breastfeeding medication should be taken with caution, strictly recommended doses under medical supervision.
Dosage and administration
The daily dose is determined individually, depending on indications. Bagotiroks a daily dose taken orally in the morning on an empty stomach, at least 30 minutes before eating, drinking pill small amount of liquid (glass of water) and not liquid.
When replacement therapy of hypothyroidism patients younger than 55 years in the absence of cardiovascular Bagotiroks diseases administered in a daily dose of 1.6 – 1.8 mg / kg body weight; in patients older than 55 years or with cardiovascular disease – 0.9 g / kg body weight. With a significant obesity calculation should be made on the “ideal weight”.
|Patients without heart disease younger than 55 years||
|Patients with cardiovascular disease or older than 55 years||
|Age||Daily dose (mg)||Calculating a dose per body weight (mg / kg)|
|> 12 years||100-200||2-3|
|testimony||Recommended dose (mg / day)|
|Treatment of euthyroid goiter||75-200|
|Prevention of relapse after surgical treatment of goiter euterioidnogo||75-200|
|In the treatment of hyperthyroidism||50-100|
|Suppressive therapy of thyroid cancer||150-300|
|Thyroid suppression test||For 4 weeks prior to the test||During the 3 weeks prior to the test||2 weeks before the test||1 week before the test|
|Bagotiroks||75 mg / day||75 mg / day||150-200 mg / day||150-200 mg / day|
Infants Bagotiroksa daily dose is given in a time of 30 minutes before the first feeding. The tablet is dissolved in water to give a fine suspension which is prepared immediately prior to administration of the drug. In patients with severe long-existing hypothyroidism treatment should be started with caution, with small doses – from 12.5 mg / day, the dose was increased to support over longer intervals – in the 12.5 mg / day every 2 weeks, and often determine the level of TSH in the blood. In hypothyroidism Bagotiroks take, as a rule, throughout their lives. When thyrotoxicosis Bagotiroks used in combination therapy with tireostatikami after achieving euthyroid state. In all cases, the duration of drug treatment determined by the doctor.
Side effects are not observed When used properly under the supervision of a physician. With increased sensitivity to the drug allergic reactions may occur.
If overdose with symptoms typical of hyperthyroidism: palpitations, cardiac arrhythmias, heart pain, anxiety, tremors, insomnia, sweating, increased appetite, weight loss, diarrhea. Depending on the severity of the symptoms your doctor may be recommended to decrease the daily dose, a break in treatment for a few days, the appointment of beta-blockers. After the disappearance of side effects of treatment should be started cautiously with lower doses.
Interaction with other medicinal products
Levothyroxine testosterone suspension gains increases the effects of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants with levothyroxine testosterone suspension gains may lead to increased action of antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended during periods of initiation of treatment with levothyroxine testosterone suspension gains, as well as changes in its dosing regimen.
Levothyroxine testosterone suspension gains reduces the effect of cardiac glycosides. With simultaneous use of cholestyramine, colestipol and aluminum hydroxide reduces the plasma concentration of testosterone suspension gains levothyroxine by its inhibition of absorption in the intestine. While the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of protein binding.
In an application with phenytoin, salicylates, clofibrate, furosemide in high doses increases the content is not associated with blood plasma proteins testosterone suspension gains and T4 levothyroxine.
Reception estrogensoderjath drugs increases the content of thyroxine-binding globulin, which can increase the need for levothyroxine testosterone suspension gains in some patients. Growth Hormone while the use of levothyroxine testosterone suspension gains may accelerate the closure of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase the clearance of levothyroxine testosterone suspension gains and require increasing doses.
In hypothyroidism, caused the defeat of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cortex simultaneously. In this case, the substitution therapy corticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency. The drug has no effect on the professional activity associated with driving vehicles and management mechanisms. shots for weight loss reviews hcg supply how much to inject for weight loss