testosterone suspension gains

When administered levothyroxine testosterone suspension gains is absorbed almost exclusively in the upper small intestine. Absorbed 80% of the dose of the drug. Food intake reduces the absorption of levothyroxine testosterone suspension gains.Maximum serum concentration is reached approximately 5-6 hours after ingestion. After absorption of more than 99% of the drug is bound to serum proteins (thyroxine-binding globulin, thyroxine binding prealbumin, and albumin). In various tissues occurs monodeyodirovanie about 80% levothyroxine testosterone suspension gains to form a triiodothyronine (T 3 ) and inactive ingredients. Thyroid hormones are metabolized mainly in the liver, kidney, brain and muscles. A small amount of the drug undergoes deamination and decarboxylation as well as sulfuric acid and conjugated with glucuronic acid (in the liver). The metabolites are excreted in the urine and bile. The half-life of 6-7 days. When thyrotoxicosis half-life is shortened to 3-4 days, and hypothyroidism is extended to 9-10 days.

Indications

  • hypothyroidism;
  • euthyroid goitre;
  • as replacement therapy and for the prevention of goiter recurrence after resection of the thyroid gland;
  • thyroid cancer (after surgery);
  • diffuse toxic goiter: after achieving euthyroid state tireostatikami (in the form of combination or monotherapy);
  • as a diagnostic tool for the test thyroid suppression.

Contraindications

  • Individual hypersensitivity to the drug;
  • Untreated hyperthyroidism;
  • acute myocardial infarction, acute myocarditis;
  • untreated adrenal insufficiency.

Precautions should be prescribed the drug for diseases of the cardiovascular system: ischemic heart disease (atherosclerosis, angina pectoris, myocardial infarction), hypertension, arrhythmia; diabetes, severe long-existing hypothyroidism, malabsorption syndrome (may require dose adjustment).

Use during pregnancy and lactation
During pregnancy and breast-feeding therapy with levothyroxine testosterone suspension gains, designated about hypothyroidism, should be continued. During pregnancy, you want to increase the dose of the drug due to increased levels of thyroxine-binding globulin. The amount of thyroid hormone secreted by breast milk during lactation (anavar for sale), is not sufficient to cause any impairment in children. Pregnancy drug in combination with tireostatikami contraindicated since receiving levothyroxine testosterone suspension gains may require an increase in dose thyreostatics. Since tireostatiki unlike levothyroxine testosterone suspension gains, can cross the placenta, the fetus may develop hypothyroidism. During the period of breastfeeding medication should be taken with caution, strictly recommended doses under medical supervision.

Dosage and administration
The daily dose is determined individually, depending on indications. Bagotiroks a daily dose taken orally in the morning on an empty stomach, at least 30 minutes before eating, drinking pill small amount of liquid (glass of water) and not liquid.
When replacement therapy of hypothyroidism patients younger than 55 years in the absence of cardiovascular Bagotiroks diseases administered in a daily dose of 1.6 – 1.8 mg / kg body weight; in patients older than 55 years or with cardiovascular disease – 0.9 g / kg body weight. With a significant obesity calculation should be made on the “ideal weight”.

The initial stage of replacement therapy in hypothyroidism
Patients without heart disease younger than 55 years
  • initial dose: Women – 75-100 mg / day, men -100-150 mcg / day
Patients with cardiovascular disease or older than 55 years
  • The initial dose – 25 mg / day
  • Increase to 25 mg at intervals of 2 months before the normalization of TSH levels in the blood
  • At occurrence or worsening of cardiac symptoms carry out the correction of cardiac therapy
The recommended dose for the treatment of congenital hypothyroidism
Age Daily dose (mg) Calculating a dose per body weight (mg / kg)
0-6 months 25-50 10-15
6-12 months 50-75 6-8
1-5 years 75-100 5-6
6-12 years 100-150 4-5
> 12 years 100-200 2-3
testimony Recommended dose (mg / day)
Treatment of euthyroid goiter 75-200
Prevention of relapse after surgical treatment of goiter euterioidnogo 75-200
In the treatment of hyperthyroidism 50-100
Suppressive therapy of thyroid cancer 150-300
Thyroid suppression test For 4 weeks prior to the test During the 3 weeks prior to the test 2 weeks before the test 1 week before the test
Bagotiroks 75 mg / day 75 mg / day 150-200 mg / day 150-200 mg / day

Infants Bagotiroksa daily dose is given in a time of 30 minutes before the first feeding. The tablet is dissolved in water to give a fine suspension which is prepared immediately prior to administration of the drug. In patients with severe long-existing hypothyroidism treatment should be started with caution, with small doses – from 12.5 mg / day, the dose was increased to support over longer intervals – in the 12.5 mg / day every 2 weeks, and often determine the level of TSH in the blood. In hypothyroidism Bagotiroks take, as a rule, throughout their lives. When thyrotoxicosis Bagotiroks used in combination therapy with tireostatikami after achieving euthyroid state. In all cases, the duration of drug treatment determined by the doctor.

Side effects
Side effects are not observed When used properly under the supervision of a physician. With increased sensitivity to the drug allergic reactions may occur.

Overdose
If overdose with symptoms typical of hyperthyroidism: palpitations, cardiac arrhythmias, heart pain, anxiety, tremors, insomnia, sweating, increased appetite, weight loss, diarrhea. Depending on the severity of the symptoms your doctor may be recommended to decrease the daily dose, a break in treatment for a few days, the appointment of beta-blockers. After the disappearance of side effects of treatment should be started cautiously with lower doses.

Interaction with other medicinal products
Levothyroxine testosterone suspension gains increases the effects of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants with levothyroxine testosterone suspension gains may lead to increased action of antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended during periods of initiation of treatment with levothyroxine testosterone suspension gains, as well as changes in its dosing regimen.
Levothyroxine testosterone suspension gains reduces the effect of cardiac glycosides. With simultaneous use of cholestyramine, colestipol and aluminum hydroxide reduces the plasma concentration of testosterone suspension gains levothyroxine by its inhibition of absorption in the intestine. While the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of protein binding.
In an application with phenytoin, salicylates, clofibrate, furosemide in high doses increases the content is not associated with blood plasma proteins testosterone suspension gains and T4 levothyroxine.
Reception estrogensoderjath drugs increases the content of thyroxine-binding globulin, which can increase the need for levothyroxine testosterone suspension gains in some patients. Growth Hormone while the use of levothyroxine testosterone suspension gains may accelerate the closure of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase the clearance of levothyroxine testosterone suspension gains and require increasing doses.

Cautions
In hypothyroidism, caused the defeat of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cortex simultaneously. In this case, the substitution therapy corticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency. The drug has no effect on the professional activity associated with driving vehicles and management mechanisms. shots for weight loss reviews hcg supply how much to inject for weight loss

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Bagomet inhibits hepatic gluconeogenesis, reduce the absorption of glucose from the intestine, increases peripheral glucose utilization and improves the sensitivity of tissues to insulin. When this has no effect on insulin secretion of pancreatic beta cells. It reduces the level of triglycerides and low-density lipoprotein in blood. Stabilizes or reduces body weight. It has fibrinolytic action due to suppression of tissue plasminogen activator inhibitor type.  After ingestion Bagomet absorbed from the gastrointestinal tract. The bioavailability after ingestion of standard doses of 50-60%. The maximum plasma concentration is reached 2 hours after ingestion. Almost does not bind to plasma proteins. It accumulates in the salivary glands, liver and kidneys. Provided unchanged by the kidneys. The half-life is about 6.5 hours. If the kidney function can be drug accumulation.

Indications

Diabetes mellitus type 2 without a tendency to ketoacidosis
(especially in patients who are obese) when poor diet.

Contraindications

  • diabetic ketoacidosis, diabetic precoma, coma;
  • pronounced renal dysfunction;
  • cardiac and respiratory failure, acute phase of myocardial infarction, acute testosterone suspension side effects cerebrovascular accident, dehydration, chronic alcoholism, and other conditions that may contribute to the development of lactic acidosis;
  • Pregnancy and breast-feeding;
  • Hypersensitivity to the drug.
  • major surgery or injury, when shown of insulin;
  • liver dysfunction, acute alcohol poisoning;
  • lactic acidosis (including history);
  • use for at least 2 days prior to and within 2 days after the radioisotope or radiological examinations introduction iodinated contrast material;
  • compliance with a hypocaloric diet (less than 1000 calories / day).

Do not use the drug in patients older than 60 years, performing heavy physical work, which is associated with an increased risk of developing lactic acidosis.

Dosage and administration
The dose is established by the doctor individually, depending on the level of glucose in the blood.
The initial dose of 500-1000 mg / day. After 10-15 days may further gradual increase in the dose depending on the glucose level. The maintenance dose is usually 1500-2000 mg / day. The maximum dose – 3000 mg / day. To reduce the side effects from the gastrointestinal tract daily dose should be divided in 2 3 receptions.
In elderly patients the recommended daily dose should not exceed 1000 mg.
Bagometa tablets should be taken as a whole during or immediately after a meal with a small amount of liquid ( a glass of water).
Due to the increased risk of lactic acidosis, Bagometa dose should be reduced in severe metabolic disorders.

Side effect On the part of the digestive organ system: nausea, vomiting, “metallic” taste in the mouth, loss of appetite, diarrhea, flatulence, abdominal pain. On the part of metabolism: rarely – lactic acidosis (requires discontinuation of treatment); long-term treatment – vitamin deficiencies in 12 (malabsorption). From the side of hematopoiesis : in some cases – megaloblastic anemia. From the Endocrine : hypoglycemia (when used in inadequate doses). Allergic testosterone suspension side effects reactions : skin rash.

Overdose

In case of overdose may develop lactic acidosis Bagometa fatal. The reason for the development of lactic acidosis may also be the accumulation of the drug due to renal dysfunction. Early symptoms of lactic acidosis include nausea, vomiting, diarrhea, drop in body temperature, abdominal pain, pain in the muscles, in the future may be marked shortness of breath, dizziness, impaired consciousness and coma develop. Treatment : In case of occurrence of lactic acidosis symptoms, treatment Bagometom you must immediately stop , the patient hospitalized immediately and determine the concentration of lactate, to confirm the diagnosis. The most effective measure for removal from the body and Bagometa lactate is hemodialysis.
Spend as symptomatic treatment.
In combination therapy with sulfonylurea Bagometa may develop hypoglycaemia.

Interaction with other medicinal products
In an application with sulfonylureas, acarbose, insulin, nonsteroidal anti-inflammatory agents, monoamine oxidase inhibitors, oxytetracycline, angiotensin converting enzyme inhibitors, clofibrate derivatives, cyclophosphamide, ß-blockers may increase the hypoglycemic effect Bagometa. While the use of corticosteroids, oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormone drugs, thiazide and “loop” diuretics, phenothiazine derivatives, derivatives of nicotinic acid may reduce the hypoglycemic action Bagometa. Cimetidine Bagometa slows down, resulting in increased risk of developing lactic acidosis.
Bagomet may weaken the effect of anticoagulants (coumarin derivatives).
Together with the admission of alcohol may develop lactic acidosis.

Cautions
During treatment necessary to monitor renal function. At least 2 times a year, as well as the appearance of myalgia should determine the content of lactate in plasma. Bagometa possible to use in testosterone suspension side effects combination with sulfonylureas. In this case, you need particularly careful monitoring of blood glucose levels. buy legal anabolic steroids online

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Combined drug, neurotropic B vitamins (thiamine, pyridoxine, cyanocobalamin) have a beneficial effect on inflammatory and degenerative diseases of the nerves and the skeletal system. They do not apply to eliminate gipovitaminoznyh states, and in high doses have analgeticheskimim properties, promote blood flow and normalize the nervous system, the process of hematopoiesis (cyanocobalamin (vitamin B12)). Vitamins Thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) regulate protein, carbohydrate and fat metabolism, promote normalization improve motor function, sensory and autonomic nerves. testosterone suspension results – local anesthetic.

Pharmacokinetics
After intramuscular thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing, 50 mg) and unevenly distributed in the body when its content in leukocytes of 15% red blood cells of 75% and plasma 10 %. Thiamine penetrates the blood-brain and placental barriers, is found in breast milk. Thiamine kidneys displayed in the alpha-phase by 0.15 hours, the beta phase – after 1 hour in the terminal phase – for 2 days. The major metabolites are tiaminkarbonovaya acid Pyramin and some unidentified metabolites. Of all the vitamins thiamine stored in the body in small amounts. An adult human contains about 30 mg of thiamine as 80% in the form of thiamine pyrophosphate, thiamine triphosphate 10% and the remainder in the form of thiamine monophosphate. After intramuscular injection of pyridoxine is rapidly absorbed from the injection site and distributed in the body, acting as a coenzyme after phosphorylation CH2OH group in the 5th position. About 80% of vitamin binds to plasma proteins. Pyridoxine is distributed throughout the body, crosses the placenta, it is found in breast milk. Stored in the liver and is oxidized to 4-pyridoxine acid which is excreted by the kidneys, a maximum 2-5 hours after absorption.

Indications for use:

In the treatment of diseases of the nervous system of various origins:

  • neuritis and polyneuritis, including optic neuritis;
  • neuralgia, including trigeminal nerve and intercostal nerves;
  • peripheral paresis, including facial nerve;
  • pain (radicular, myalgia);
  • plexopathy, ganglionitis (including herpes zoster);
  • neuropathy and polyneuropathy (diabetic, alcohol, etc..);
  • nocturnal muscle cramps, especially in patients of older age groups;
  • neurological manifestations of osteochondrosis (radiculopathy, sciatica, muscular-tonic syndrome).

 

Contraindications:

 

  • Hypersensitivity to the drug;
  • acute heart failure, chronic heart failure in the stage of decompensation;
  • thrombosis and thromboembolism;
  • Children up to age 18 years (effectiveness and safety have not been established).

 

Pregnancy and lactation

During pregnancy and lactation is not recommended to use the drug.

Dosing and Administration

The drug is recommended to be administered intramuscularly deeply. Duration of treatment is determined by the physician individually depending on the severity of symptoms.

When expressed pain syndrome 2 ml (1 ampoule) daily for 5-10 days, followed by 2 ml (1 ampoule) 2-3 times a week in the credit score to 2 weeks. For maintenance therapy is recommended that use of oral forms of vitamin B.

Side effect

Allergic reactions (skin reactions such as pruritus, urticaria), sweating, tachycardia, may cause acne, dyspnea, angioedema, anaphylactic shock.

In cases of very rapid administration may be systemic adverse reactions (dizziness, headache, arrhythmia, seizures), they can also be the result of an overdose.

If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

Overdose

Symptoms: increased side effects of the drug symptoms. Treatment: symptomatic therapy.

Interaction with other drugs

Thiamine completely dissolves in solutions containing sulphites. Other vitamins thiamine inactivated in the presence of degradation products. Thiamine is incompatible with oxidizing and reducing substances: mercuric chloride, iodide, carbonate, acetate, tannic acid, ammonium-iron-citrate and phenobarbital, riboflavin, benzylpenicillin, dextrose and metabisulfite. Copper ions, the values of pH (greater than 3.0) accelerate the destruction of thiamine.

Pyridoxine is not administered with levodopa, tsiklossrinom, D-penicillamine, epinephrine, porepinefrinom, sulfonamides, which reduce the effect of pyridoxine.

Cyanocobalamin is incompatible with ascorbic acid, salts of heavy metals. Taking into account the presence in the formulation of testosterone suspension results in case of the additional use of epinephrine and norepinephrine possible increased side effects on the heart. In case of overdose of local anesthetics can not be further used epinephrine and norepinephrine.

Product form:

The solution for intramuscular injection.

2 ml of the drug in the ampule lightproof neutral glass.

5 vials are placed in a contoured plastic packaging (pallet) from polyvinyl chloride film, or polyethylene terephthalate film.

5 vials are placed in blisters made of PVC film or polyethylene terephthalate film, aluminum foil and printed patent or packaging material.

1, 2, 4-outline plastic packages (pallets) or blisters with ampoules, together with instructions for use and a knife or lancet ampoule ampoule is placed in a pile of cardboard.

5, 10, 20 ampoules but with instruction use and knife or lancet ampoule ampoule is placed in a wad of cardboard divider insert. When using ampoules with a color break point and a notch or color break-ring, knife scarifier ampoule or ampoule do not invest. anabolic steroids online shop

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Aceclofenac has anti-inflammatory, analgesic and antipyretic activity. It inhibits synthesis of prostaglandins and thus affects the pathogenesis of inflammation, pain and fever occurrence. In rheumatic diseases inflammatory and analgesic effect of aceclofenac contributes to a significant reduction in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the patient.

Aceclofenac is rapidly and completely absorbed after oral administration. Time to maximum concentration -. 1.25-3 h penetrates into the synovial fluid, where its concentration reaches 57% of the level of concentration in plasma and the time to reach maximum concentration at 2-4 hours later than in plasma. The volume of distribution – 25 l.
The connection to plasma proteins (albumin) – 99%. Aceclofenac circulates mainly in unchanged form, its main metabolite is 4′-gidroksiatseklofenak.
The half-life -. 4 hours excreted by the kidneys, mainly in the form of hydroxy (about 2/3 of the administered dose).

Indications
Symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. Rheumatism of soft tissues, accompanied by pain.

Contraindications
– erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding or suspicion of it;
– a history of bronchial obstruction, urticaria, rhinitis, after taking aspirin or other NSAIDs (complete or partial syndrome of intolerance to acetylsalicylic acid – rhinosinusitis , urticaria, polyps of the nasal mucosa, bronchial asthma);
– hypersensitivity to aceclofenac or components of the preparation;
– the period after coronary artery bypass surgery;
– severe hepatic impairment or active liver disease;
– violation of hematopoiesis and coagulation;
– severe renal failure, progressive renal disease confirmed hyperkalemia;
– pregnancy and lactation
– children under 18 years old.

Precautions
Liver disease, kidney and gastrointestinal tract in the history of bronchial asthma, hypertension, decreased blood volume (including immediately after major surgery), coronary heart disease, chronic kidney, liver and heart failure, creatinine clearance less than 60 ml / min, medical history data about the development of ulcerative lesions gastrointestinal tract, the presence of Helicobacter pylory infection, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral vascular disease, smoking, advanced age, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases.

Pregnancy and lactation
The drug is contraindicated during pregnancy (see. Section “Contraindications”). Information Aertala use during pregnancy is not available. Regular use of NSAIDs in the last trimester of pregnancy can lead to a decrease in tone and weaker contractions. The use of NSAIDs may cause premature closure of the arterial duct in the fetus and possibly to a prolonged pulmonary hypertension of the newborn, delayed onset of labor and an increase in the duration of labor.
In epidemiological studies have not received data in humans, indicating the toxicity of NSAIDs for the embryo. However, in experiments on rabbits assignment aceclofenac (10 mg / kg / day) in some cases resulted in a number of morphological changes in the fetus. Data on the presence of a teratogenic effect in rats no. Lactation: Aertal should not be taken during lactation (see section “Contraindications”.).Data on the allocation of Aertala with human milk is not available; when assigning radioactive 14 P-lactating rats aceclofenac appreciable transfer of radioactivity was observed in the milk.

Dosage and administration.
Inside. The buy testosterone suspensions should be swallowed whole, drinking plenty of fluids.
Usually adults appoint 1 buy testosterone suspension of 100 mg 2 times a day; one buy testosterone suspension in the morning and one – in the evening.

Side effect On the part of the digestive tract: nausea, vomiting, diarrhea, epigastric pain, intestinal colic, dyspepsia, flatulence, anorexia, constipation; in rare cases, noted the appearance of erosive and ulcerative lesions, bleeding or perforation of the gastrointestinal tract (hematemesis, melena), stomatitis including aphthous, pancreatitis. From the nervous system: sometimes marked headache, dizziness, sleep disturbances (insomnia or drowsiness) , agitation, in some cases, marked sensory disturbances, disorientation, impaired memory, vision, hearing, taste, tinnitus, convulsions, irritability, tremor, depression, anxiety, vertigo, aseptic meningitis, paresthesia. Allergic manifestations: sometimes a skin rash rarely – urticaria, marked individual cases of eczema, erythema multiforme, erythroderma, rarely observed bouts of bronchial asthma; systemic anaphylactic reactions, in some cases, vasculitis, pneumonitis, Stevens – Johnson and Lyell’s syndrome, anaphylactic shock. On the part of the kidney: rarely peripheral edema, in some cases, acute renal failure, interstitial nephritis, nephrotic syndrome, hematuria, proteinuria. Liver : . transient increase in transaminases in the blood, rarely – hepatitis, in some cases, fulminant hepatitis Hematopoietic system: leukopenia, described isolated cases of thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia. cardio-vascular system: marked by sporadic cases of tachycardia, hypertension, congestive heart failure, coronary artery disease.

Overdose

Symptoms:
The clinical picture is determined disorders of the central nervous system (headache, dizziness, hyperventilation phenomenon with increased convulsive readiness) and gastrointestinal disorders (abdominal pain, nausea, vomiting).

Treatment:
In case of overdose shown gastric lavage, administration of activated charcoal, symptomatic therapy. There is no specific antidote. Forced diuresis, dialysis, blood transfusions – are ineffective.

Interaction with other medicinal products
In an application and AERTALA:

 

  • digoxin, phenytoin or lithium preparations – may increase plasma levels of these drugs;
  • diuretics and antihypertensives – can weaken the effect of these funds;
  • potassium-sparing diuretics – may lead to hyperglycemia and hyperkalemia;
  • other NSAIDs or glucocorticosteroids – increases the risk of side effects from the gastrointestinal tract;
  • Selective serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) – increase the risk of gastrointestinal bleeding;
  • cyclosporine – may increase the toxic effect of the latter on the kidneys;
  • antidiabetic agents – can cause both hypo- and hyperglycemia. With this combination of resources necessary to monitor blood sugar levels;
  • methotrexate for 24 hours before or after administration – may lead to increased concentrations of methotrexate to enhance its toxic effect;
  • acetylsalicylic acid reduces the concentration of aceclofenac in the blood;
  • antiplatelet agents and anticoagulants – the risk of bleeding (requires regular monitoring of blood clotting).Effects on ability to drive and control mechanisms for
    patients suffering from vertigo and other disorders of the central nervous system while taking Aertala should refrain from driving and working with dangerous machinery.Cautions
    In the period of drug treatment should be systematic monitoring of peripheral blood, liver, kidney, feces study on the presence of blood. Patients receiving the drug should refrain from activities requiring increased attention and rapid mental and motor reactions, the use of alcohol.
    Because of the important role of prostaglandins in maintaining renal blood flow should be particularly careful when administered to patients with cardiac or renal insufficiency, elderly taking diuretics, and patients with a reduced volume of circulating blood (such as after major surgery). If in such cases appoint aceclofenac, it is recommended to monitor renal function. In patients with hepatic impairment the kinetics and metabolism differ from analogichngh processes in patients with normal liver function.
    To reduce the risk of adverse effects on the gastrointestinal tract to use the minimum effective dose as low as possible short course.

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The presence in the structure acetylcysteine sulfhydryl groups helps break the disulfide bonds, acid mucopolysaccharides mucus, which leads to a reduction of mucus viscosity. The drug remains active in the presence of purulent sputum. When prophylactic use of acetylcysteine marked decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Indications
Respiratory diseases accompanied by formation viscous sputum; acute and chronic bronchitis, obstructive bronchitis, laryngotracheitis, pneumonia, bronchiectasis, asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis, cystic fibrosis. Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications
Increased sensitivity to acetylcysteine or other components of the drug, pregnancy, lactation. Be wary – gastric ulcer and duodenal ulcer in the acute stage;hemoptysis, pulmonary hemorrhage, esophageal varices, asthma, diseases of the adrenal glands, liver and / or kidney failure, children up to 2 years (use is possible only if there is evidence of life and strict medical supervision).

Pregnancy and lactation
The safety measures due to insufficient amount of data, use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Dosing and Administration
In the absence of other nominations recommended to adhere to the following dosage: Adults and adolescents over the age of 14 years: It is recommended to take 2-3 times a day for 2 scoops (= 10 ml) of the drug, which corresponds to receiving 400-600 mg of acetylcysteine day.

Children aged 6-14 years:
It is recommended to take 3-4 times a day for 1 measuring spoon (= 5 ml) of the drug, which corresponds to receiving 300-400 mg of acetylcysteine per day.

Children aged 2-5 years:
It is recommended to take 2-3 times a day for 1 measuring spoon (= 5 ml) of the drug. corresponding reception 200-300 mg per day acetylcysteine.

Children less than 2 years (only on doctor’s orders):
It is recommended to take 2-3 times a day for Vz measuring spoon (= 2.5 ml) of the drug, which corresponds to receiving 100-150 mg of acetylcysteine per day,

There is a sufficient amount of the dosage of the drug in the newborn data.

Cystic fibrosis
patients with cystic fibrosis (an inborn error of metabolism with frequent infections of the bronchial passages) and weighing more than 30 kg is possible to increase the daily dose to 800 mg.

Children over the age of b years: Recommended 3 times daily intake of 2 scoops (= 10 ml) of the drug, corresponding to receive 600 mg of acetylcysteine per day.

Children 2-6 years:
Recommended 4 times daily administration and 1 scoop of the preparation (= 5 mL), which corresponds to receiving 400 mg per day acetylcysteine.

Infants, starting from the 10th day of life, or small children aged less than 2 years:
Recommended 3 times daily intake by 1/2 measuring spoon of the drug (= 2.5 ml), which corresponds to receiving 150 mg of acetylcysteine per day .
Treatment should be started gradually under medical supervision.

Additional fluid intake increases the mucolytic effect of the drug.
In the short-term duration of colds reception is 5-7 days. At long disease duration of therapy is determined by the attending physician. In chronic bronchitis and cystic fibrosis drug should be taken over a long period of time to achieve a preventive effect against infections.

Note for diabetics:
10 ml (= 2 scoops) of ready-to-drink testosterone suspension reviews contain 3,7g D-glucitol (sorbitol), which corresponds to the 0S31 BE.

Side effects:
In rare cases, there are headaches, inflammation of the oral mucosa (stomatitis), and tinnitus. Very rarely – diarrhea, vomiting, heartburn and nausea, decreased blood pressure, increased heart rate (tachycardia). In rare cases, allergic reactions such as bronchospasm (predominantly in patients with bronchial hyperreactivity), skin rash, itching and hives. In addition, there are few reports of bleeding due to the presence of hypersensitivity reactions.
In developing side effects should stop taking the drug and consult a doctor.

Overdose
If erroneous or deliberate overdose observed phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea. Until now there was no serious and life-threatening side effects.

Interaction with other drugs
With simultaneous use of acetylcysteine and antitussives because of the suppression of the cough reflex may be stagnant mucus. Therefore, such combinations should be selected with caution.Simultaneous administration of acetylcysteine and nitroglycerin may lead to increased vasodilatory action subsequent. Pharmaceutical incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.
In contact with metals, rubber formed sulfides with a characteristic odor.

Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after oral administration of acetylcysteine).

Cautions
Patients with bronchial asthma and obstructive bronchitis acetylcysteine should be used with caution under systematic control of bronchial obstruction.
In the treatment of patients with diabetes need to take into account that the drug contains sorbiton.
When working with the preparation necessary to use glassware, avoid contact with metal, rubber, oxygen, oxidizing agents easily.

Issuance
Granules for testosterone suspension reviews (orange).
30 g of granulate for the preparation of 75 ml of testosterone suspension reviews in a bottle of dark glass or
60 g of granulate for the preparation of 150 ml of testosterone suspension reviews in a bottle of dark glass.
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